Polyphenols from Salix tetrasperma Impair Virulence and Inhibit Quorum Sensing of Pseudomonas aeruginosa.
Identifieur interne : 000124 ( Main/Exploration ); précédent : 000123; suivant : 000125Polyphenols from Salix tetrasperma Impair Virulence and Inhibit Quorum Sensing of Pseudomonas aeruginosa.
Auteurs : Islam Mostafa [Égypte] ; Hisham A. Abbas [Égypte] ; Mohamed L. Ashour [Égypte] ; Abdelaziz Yasri [Maroc] ; Assem M. El-Shazly [Égypte] ; Michael Wink [Allemagne] ; Mansour Sobeh [Maroc, Allemagne]Source :
- Molecules (Basel, Switzerland) [ 1420-3049 ] ; 2020.
Abstract
Bacterial resistance represents one of the emerging obstacles in plants, animals, and humans that impairs treatment with antibacterial agents. Targeting of the bacterial quorum sensing system is one of the strategies to overcome this problem. Recently, research has been focused on natural and food components which can function as quorum sensing inhibitors. In this study, a methanol extract from Salix tetrasperma stem bark was phytochemically profiled by LC-MS analysis. This resulted in the identification of 38 secondary metabolites with (epi)catechin-(epi)catechin, epicatechin, tremulacin, salicortin, and trichocarposide as the major constituents. The extracts of both stem bark and the previously profiled flower of S. tetrasperma were tested for anti-quorum sensing activity in a common and widely distributed pathogen Pseudomonas aeruginosa. The natural products inhibited swimming and swarming motilities, as well as proteolytic and hemolytic activities in a dose-dependent manner. Molecular docking of the constituents from both extracts against the quorum sensing controlling systems Lasl/LasR, rhll/rhlR, and PQS/MvfR showed that epicatechin, (epi)catechin-(epi)catechin, p-hydroxy benzoyl galloyl glucose, p-hydroxy benzoyl protocatechuic acid glucose, and caffeoylmalic acid could be the main active components. This study supports the importance of secondary metabolites, especially polyphenols, as quorum sensing inhibitors.
DOI: 10.3390/molecules25061341
PubMed: 32187997
PubMed Central: PMC7146421
Affiliations:
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Abbas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig 44519</wicri:regionArea><wicri:noRegion>Zagazig 44519</wicri:noRegion></affiliation></author><author><name sortKey="Ashour, Mohamed L" sort="Ashour, Mohamed L" uniqKey="Ashour M" first="Mohamed L" last="Ashour">Mohamed L. Ashour</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo 11566</wicri:regionArea><wicri:noRegion>Cairo 11566</wicri:noRegion></affiliation></author><author><name sortKey="Yasri, Abdelaziz" sort="Yasri, Abdelaziz" uniqKey="Yasri A" first="Abdelaziz" last="Yasri">Abdelaziz Yasri</name><affiliation wicri:level="1"><nlm:affiliation>AgroBioSciences Research Division, Mohammed VI Polytechnic University, Lot 660-Hay MoulayRachid, Ben-Guerir 43150, Morocco.</nlm:affiliation><country xml:lang="fr">Maroc</country><wicri:regionArea>AgroBioSciences Research Division, Mohammed VI Polytechnic University, Lot 660-Hay MoulayRachid, Ben-Guerir 43150</wicri:regionArea><wicri:noRegion>Ben-Guerir 43150</wicri:noRegion></affiliation></author><author><name sortKey="El Shazly, Assem M" sort="El Shazly, Assem M" uniqKey="El Shazly A" first="Assem M" last="El-Shazly">Assem M. El-Shazly</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig 44519</wicri:regionArea><wicri:noRegion>Zagazig 44519</wicri:noRegion></affiliation></author><author><name sortKey="Wink, Michael" sort="Wink, Michael" uniqKey="Wink M" first="Michael" last="Wink">Michael Wink</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, 69120 Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, 69120 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Sobeh, Mansour" sort="Sobeh, Mansour" uniqKey="Sobeh M" first="Mansour" last="Sobeh">Mansour Sobeh</name><affiliation wicri:level="1"><nlm:affiliation>AgroBioSciences Research Division, Mohammed VI Polytechnic University, Lot 660-Hay MoulayRachid, Ben-Guerir 43150, Morocco.</nlm:affiliation><country xml:lang="fr">Maroc</country><wicri:regionArea>AgroBioSciences Research Division, Mohammed VI Polytechnic University, Lot 660-Hay MoulayRachid, Ben-Guerir 43150</wicri:regionArea><wicri:noRegion>Ben-Guerir 43150</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, 69120 Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, 69120 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author></analytic><series><title level="j">Molecules (Basel, Switzerland)</title><idno type="eISSN">1420-3049</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bacterial resistance represents one of the emerging obstacles in plants, animals, and humans that impairs treatment with antibacterial agents. Targeting of the bacterial quorum sensing system is one of the strategies to overcome this problem. Recently, research has been focused on natural and food components which can function as quorum sensing inhibitors. In this study, a methanol extract from <i>Salix tetrasperma</i> stem bark was phytochemically profiled by LC-MS analysis. This resulted in the identification of 38 secondary metabolites with (epi)catechin-(epi)catechin, epicatechin, tremulacin, salicortin, and trichocarposide as the major constituents. The extracts of both stem bark and the previously profiled flower of <i>S. tetrasperma</i> were tested for anti-quorum sensing activity in a common and widely distributed pathogen <i>Pseudomonas aeruginosa</i>. The natural products inhibited swimming and swarming motilities, as well as proteolytic and hemolytic activities in a dose-dependent manner. Molecular docking of the constituents from both extracts against the quorum sensing controlling systems Lasl/LasR, rhll/rhlR, and PQS/MvfR showed that epicatechin, (epi)catechin-(epi)catechin, <i>p</i>-hydroxy benzoyl galloyl glucose, <i>p</i>-hydroxy benzoyl protocatechuic acid glucose, and caffeoylmalic acid could be the main active components. This study supports the importance of secondary metabolites, especially polyphenols, as quorum sensing inhibitors.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32187997</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>16</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1420-3049</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>6</Issue><PubDate><Year>2020</Year><Month>Mar</Month><Day>16</Day></PubDate></JournalIssue><Title>Molecules (Basel, Switzerland)</Title><ISOAbbreviation>Molecules</ISOAbbreviation></Journal><ArticleTitle>Polyphenols from <i>Salix tetrasperma</i> Impair Virulence and Inhibit Quorum Sensing of <i>Pseudomonas aeruginosa</i>.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E1341</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/molecules25061341</ELocationID><Abstract><AbstractText>Bacterial resistance represents one of the emerging obstacles in plants, animals, and humans that impairs treatment with antibacterial agents. Targeting of the bacterial quorum sensing system is one of the strategies to overcome this problem. Recently, research has been focused on natural and food components which can function as quorum sensing inhibitors. In this study, a methanol extract from <i>Salix tetrasperma</i> stem bark was phytochemically profiled by LC-MS analysis. This resulted in the identification of 38 secondary metabolites with (epi)catechin-(epi)catechin, epicatechin, tremulacin, salicortin, and trichocarposide as the major constituents. The extracts of both stem bark and the previously profiled flower of <i>S. tetrasperma</i> were tested for anti-quorum sensing activity in a common and widely distributed pathogen <i>Pseudomonas aeruginosa</i>. The natural products inhibited swimming and swarming motilities, as well as proteolytic and hemolytic activities in a dose-dependent manner. Molecular docking of the constituents from both extracts against the quorum sensing controlling systems Lasl/LasR, rhll/rhlR, and PQS/MvfR showed that epicatechin, (epi)catechin-(epi)catechin, <i>p</i>-hydroxy benzoyl galloyl glucose, <i>p</i>-hydroxy benzoyl protocatechuic acid glucose, and caffeoylmalic acid could be the main active components. This study supports the importance of secondary metabolites, especially polyphenols, as quorum sensing inhibitors.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mostafa</LastName><ForeName>Islam</ForeName><Initials>I</Initials><Identifier Source="ORCID">0000-0002-6437-5528</Identifier><AffiliationInfo><Affiliation>Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abbas</LastName><ForeName>Hisham A</ForeName><Initials>HA</Initials><Identifier Source="ORCID">0000-0002-2429-327X</Identifier><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ashour</LastName><ForeName>Mohamed L</ForeName><Initials>ML</Initials><Identifier Source="ORCID">0000-0002-9270-6267</Identifier><AffiliationInfo><Affiliation>Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yasri</LastName><ForeName>Abdelaziz</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0002-7513-9037</Identifier><AffiliationInfo><Affiliation>AgroBioSciences Research Division, Mohammed VI Polytechnic University, Lot 660-Hay MoulayRachid, Ben-Guerir 43150, Morocco.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>El-Shazly</LastName><ForeName>Assem M</ForeName><Initials>AM</Initials><Identifier Source="ORCID">0000-0001-6124-7531</Identifier><AffiliationInfo><Affiliation>Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wink</LastName><ForeName>Michael</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0002-7875-4510</Identifier><AffiliationInfo><Affiliation>Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, 69120 Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sobeh</LastName><ForeName>Mansour</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0002-2719-8534</Identifier><AffiliationInfo><Affiliation>AgroBioSciences Research Division, Mohammed VI Polytechnic University, Lot 660-Hay MoulayRachid, Ben-Guerir 43150, Morocco.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, 69120 Heidelberg, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Molecules</MedlineTA><NlmUniqueID>100964009</NlmUniqueID><ISSNLinking>1420-3049</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Pseudomonas aeruginosa</Keyword><Keyword MajorTopicYN="N">Salix tetrasperma</Keyword><Keyword MajorTopicYN="N">molecular modeling</Keyword><Keyword MajorTopicYN="N">plant pathogen</Keyword><Keyword MajorTopicYN="N">quorum sensing</Keyword><Keyword MajorTopicYN="N">virulence inhibition</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>02</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>03</Month><Day>10</Day></PubMedPubDate><PubMedPubDate 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Abbas</name><name sortKey="Ashour, Mohamed L" sort="Ashour, Mohamed L" uniqKey="Ashour M" first="Mohamed L" last="Ashour">Mohamed L. Ashour</name><name sortKey="El Shazly, Assem M" sort="El Shazly, Assem M" uniqKey="El Shazly A" first="Assem M" last="El-Shazly">Assem M. El-Shazly</name></country><country name="Maroc"><noRegion><name sortKey="Yasri, Abdelaziz" sort="Yasri, Abdelaziz" uniqKey="Yasri A" first="Abdelaziz" last="Yasri">Abdelaziz Yasri</name></noRegion><name sortKey="Sobeh, Mansour" sort="Sobeh, Mansour" uniqKey="Sobeh M" first="Mansour" last="Sobeh">Mansour Sobeh</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Wink, Michael" sort="Wink, Michael" uniqKey="Wink M" first="Michael" last="Wink">Michael Wink</name></region><name sortKey="Sobeh, Mansour" sort="Sobeh, Mansour" uniqKey="Sobeh M" first="Mansour" last="Sobeh">Mansour Sobeh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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